Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion.

نویسندگان

  • Yuki Tanaka
  • Tadahiro Suenaga
  • Misako Matsumoto
  • Tsukasa Seya
  • Hisashi Arase
چکیده

The human herpesvirus 6 (HHV-6) envelope glycoprotein gH/gL/gQ1/gQ2 complex associates with host cell CD46 as its cellular receptor. Although gB has been suggested to be involved in HHV-6 infection, its function in membrane fusion has remained unclear. Here, we have developed an HHV-6A (strain GS)and HHV-6B (strain Z29) virus-free cell-to-cell fusion assay and demonstrate that gB and the gH/gL/gQ1/gQ2 complex are the minimum components required for membrane fusion by HHV-6.

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عنوان ژورنال:
  • Journal of virology

دوره 87 19  شماره 

صفحات  -

تاریخ انتشار 2013